Nicotinic Acetylcholine Receptor Signaling in Tumor Growth and Metastasis
نویسندگان
چکیده
منابع مشابه
Nicotinic Acetylcholine Receptor Signaling in Tumor Growth and Metastasis
Cigarette smoking is highly correlated with the onset of a variety of human cancers, and continued smoking is known to abrogate the beneficial effects of cancer therapy. While tobacco smoke contains hundreds of molecules that are known carcinogens, nicotine, the main addictive component of tobacco smoke, is not carcinogenic. At the same time, nicotine has been shown to promote cell proliferatio...
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The nicotinic acetylcholine receptor (nAChR) is a cation-selective channel central to both neuronal and muscular processes and is considered the prototype for ligand-gated ion channels, motivating a structural determination effort that spanned several decades [Unwin N (2005) Refined structure of the nicotinic acetylcholine receptor at 4 A resolution. J Mol Biol 346:967-989]. Purified nAChR must...
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ژورنال
عنوان ژورنال: Journal of Oncology
سال: 2011
ISSN: 1687-8450,1687-8469
DOI: 10.1155/2011/456743